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SIRT5 antibody

CAT: 0710-FNab07883Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07883Size:100 µg
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Background
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693) . Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693) . Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062) . Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity) . Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Synonyms
NAD-dependent protein deacylase sirtuin-5, mitochondrial|Regulatory protein SIR2 homolog 5|SIR2-like protein 5|SIRT5|SIR2L5
UniProt
Q9NXA8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Sirtuin (silent mating type information regulation 2 homolog) 5
Target
SIRT5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

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