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RSAD2 antibody

CAT: 0710-FNab07504Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07504Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1) . Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR) -mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
Synonyms
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) |Cytomegalovirus-induced gene 5 protein|Radical S-adenosyl methionine domain-containing protein 2|Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin) |RSAD2|CIG5
Gene ID
91543
UniProt
Q8WXG1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Radical S-adenosyl methionine domain containing 2
Target
RSAD2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC

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