PTGES3 antibody

• Background :

  Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363) . Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419) . Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448) .

• Synonyms :

  Prostaglandin E synthase 3|Cytosolic prostaglandin E2 synthase (cPGES) |Hsp90 co-chaperone|Progesterone receptor complex p23|Telomerase-binding protein p23|PTGES3|P23|TEBP

• Gene ID :

  10728

• UniProt :

  Q15185

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Prostaglandin E synthase 3 (cytosolic)

• Target :

  PTGES3

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, IF, IP, WB, FC

• Field of Research :

  Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IP: 1:200-1:2000; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  21-23 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, IF, IP, WB, FC