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PTGS2 antibody

CAT: 0710-FNab10407Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10407Size:100 µg
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Background
COX2 (Prostaglandin G/H synthase 2; PTGS2) mediates the formation of prostaglandins from arachidonate. Its subunit structure is homodimer. The fully N-glycosylated PTGS2 is 72–74 kDa and the aglycosylated is 66 kDa (PMID:19656660) . It also expresses a band of 39 kDa after unspecific cleavage (PMID:17509125) . The 50 kDa band of fragmented PTGS2 has also previously been detected in AD brains (PMID:14724276) .
Synonyms
Prostaglandin G/H synthase 2|Cyclooxygenase-2 (COX-2) |PHS II|Prostaglandin H2 synthase 2 (PGH synthase 2, PGHS-2) |Prostaglandin-endoperoxide synthase 2|PTGS2|COX2
Gene ID
5743
UniProt
P35354
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Target
PTGS2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cancer, Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa, 80 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
104-209aa

UniProtKB · P35354

Prostaglandin G/H synthase 2

PGH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35354
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTGS2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.99.1
Processing
Precursor
Secondary accessions
A8K802, Q16876
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinS-nitrosylation

Molecular function

DioxygenaseOxidoreductasePeroxidase

Cellular component

Endoplasmic reticulumMembraneMicrosomeNucleus

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolismProstaglandin biosynthesisProstaglandin metabolism

Ligand

HemeIronMetal-binding

Domain

Signal

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