PPARA antibody

• Background:

  Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

• Synonyms:

  Peroxisome proliferator-activated receptor alpha (PPAR-alpha) |Nuclear receptor subfamily 1 group C member 1|PPARA|NR1C1|PPAR

• Gene ID:

  5465

• UniProt:

  Q07869

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Peroxisome proliferator-activated receptor alpha

• Target:

  PPARA

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:1000; IHC: 1:50-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  52-55 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  1-468