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PLEKHO1 antibody

CAT: 0710-FNab06543Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06543Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP) . May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2) . Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Synonyms
Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) |C-Jun-binding protein (JBP) |Casein kinase 2-interacting protein 1 (CK2-interacting protein 1, CKIP-1) |Osteoclast maturation-associated gene 120 protein|PLEKHO1|CKIP1|OC120
Gene ID
51177
UniProt
Q53GL0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Pleckstrin homology domain containing, family O member 1
Target
PLEKHO1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46, 90 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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