PIN1 antibody

PIN1 antibody

• Background: Peptidyl-prolyl cis/trans isomerase(PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro(pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins(PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK(PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation(PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner(PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN(PubMed:22608923).
• Synonyms: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1)|Rotamase Pin1|PIN1
• CAS Number: 9007-83-4
• Gene ID: 5300
• UniProt: Q13526
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Immunogen: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
• Target: PIN1
• Clonality: Polyclonal
• Isotype: IgG
• Applications: ELISA, WB, IHC, IP
• Field of Research: Metabolism, Immunology, Cell Division and Proliferation, Cancer
• Purification: Immunogen affinity purified
• Dilution: WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
• Purity: ≥95% as determined by SDS-PAGE
• Form: Liquid
• Molecular Weight: 18 kDa
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)