PIN1 antibody

Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920) . Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721) . Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191) . Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269) . Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923) .

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|Peptidyl-prolyl cis-trans isomerase Pin1 (PPIase Pin1) |Rotamase Pin1|PIN1

5300

Q13526

Human, Mouse, Rat

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

PIN1

ELISA, WB, IHC, IP

Metabolism, Immunology, Cell Division and Proliferation, Cancer

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

18 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)