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PHACTR4 antibody

CAT: 0710-FNab06371Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab06371Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity) .
Synonyms
Phosphatase and actin regulator 4|PHACTR4
Gene ID
65979
UniProt
Q8IZ21
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Phosphatase and actin regulator 4
Target
PHACTR4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
71-85 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

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