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NKX2-2 antibody

CAT: 0710-FNab05750Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05750Size:100 µg
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Background
Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity) .
Synonyms
Homeobox protein Nkx-2.2|Homeobox protein NK-2 homolog B|NKX2-2|NKX2.2|NKX2B
Gene ID
4821
UniProt
O95096
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
NK2 homeobox 2
Target
NKX2-2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Epigenetics, Metabolism, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
30 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

UniProtKB · O95096

Homeobox protein Nkx-2.2

NKX22_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95096
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NKX2-2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Molecular function

ActivatorDevelopmental proteinDNA-binding

Domain

Homeobox

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation