MSH6 antibody

CAT: 0710-FNab05375Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab05375Size:100 µg
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Background
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Synonyms
DNA mismatch repair protein Msh6 (hMSH6) |G/T mismatch-binding protein (GTBP, GTMBP) |MutS protein homolog 6|MutS-alpha 160 kDa subunit (p160) |MSH6|GTBP
Gene ID
2956
UniProt
P52701
Host
Rabbit
Reactivity
Human, Mouse, Monkey
Immunogen
MutS homolog 6
Target
MSH6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Metabolism, Cancer, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
160 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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