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MSH3 antibody

CAT: 0710-FNab05373Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05373Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the post-replicative DNA mismatch repair system (MMR) . Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Synonyms
DNA mismatch repair protein Msh3 (hMSH3) |Divergent upstream protein (DUP) |Mismatch repair protein 1 (MRP1) |MSH3|DUC1|DUG
Gene ID
4437
UniProt
P20585
Host
Rabbit
Reactivity
Human
Immunogen
MutS homolog 3
Target
MSH3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism, Cancer, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
123 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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