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MMP12 antibody

CAT: 0710-FNab05234Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05234Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MMP12 (Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form (15723202) . MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis (PMID: 21378275) .
Synonyms
Macrophage metalloelastase (MME) |Macrophage elastase (ME, hME) |Matrix metalloproteinase-12 (MMP-12) |MMP12|HME
Gene ID
4321
UniProt
P39900
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Matrix metallopeptidase 12 (macrophage elastase)
Target
MMP12
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa, 45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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