MMP14 antibody

CAT: 0710-FNab05236Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab05236Size:100 µg
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Synonyms
Matrix metalloproteinase-14 (MMP-14) |MMP-X1|Membrane-type matrix metalloproteinase 1 (MT-MMP 1, MTMMP1) |Membrane-type-1 matrix metalloproteinase (MT1-MMP, MT1MMP) |MMP14
Gene ID
4323
UniProt
P50281
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Matrix metallopeptidase 14 (membrane-inserted)
Target
MMP14
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cancer, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
100-200aa, Extracellular domain

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