MMP14 antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

• Synonyms:

  Matrix metalloproteinase-14 (MMP-14) |MMP-X1|Membrane-type matrix metalloproteinase 1 (MT-MMP 1, MTMMP1) |Membrane-type-1 matrix metalloproteinase (MT1-MMP, MT1MMP) |MMP14

• Gene ID:

  4323

• UniProt:

  P50281

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Matrix metallopeptidase 14 (membrane-inserted)

• Target:

  MMP14

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Cancer, Cardiovascular, Metabolism, Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  65 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  100-200aa, Extracellular domain