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MGAT5B antibody

CAT: 0710-FNab05161Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab05161Size:100 µg
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Background
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3-and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway.
Synonyms
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B|Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B|GlcNAc-T Vb (GNT-Vb, hGnTVb) |Mannoside acetylglucosaminyltransferase 5B|N-acetylglucosaminyl-transferase Vb|N-acetylglucosaminyltransferase IX (GNT-IX) |MGAT5B|KIAA2008
Gene ID
146664
UniProt
Q3V5L5
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Mannosyl (alpha-1,6-) -glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
Target
MGAT5B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
89-100 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP

UniProtKB · Q3V5L5

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

MGT5B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q3V5L5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MGAT5B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.4.1.-, 2.4.1.155
Processing
—
Secondary accessions
Q6P3S8, Q6P6B3, Q766X5, Q76D04, Q96LS2
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Molecular function

GlycosyltransferaseTransferase

Cellular component

Golgi apparatusMembrane

Ligand

ManganeseMetal-binding

Technical term

Proteomics identificationReference proteome

Domain

Signal-anchorTransmembraneTransmembrane helix

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