KIDINS220 antibody

CAT: 0710-FNab04549Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab04549Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF) -induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity) . Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Synonyms

Kinase D-interacting substrate of 220 kDa|Ankyrin repeat-rich membrane-spanning protein|KIDINS220|ARMS|KIAA1250

Gene ID

57498

UniProt

Q9ULH0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Kinase D-interacting substrate, 220kDa

Target

KIDINS220

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Field of Research

Signal Transduction

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

186-197 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB

UniProtKB · Q9ULH0

Kinase D-interacting substrate of 220 kDa

KDIS_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9ULH0
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KIDINS220
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A1L4N4, Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeatTransmembraneTransmembrane helix

Disease

Disease variantHereditary spastic paraplegiaIntellectual disabilityNeurodegenerationObesity

Cellular component

EndosomeMembrane

Biological process

Neurogenesis

PTM

Phosphoprotein

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Alternative Products

Catalog	Name
70R-18109	KIDINS220 antibody