KANK1 antibody

• Background:

  Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

• Synonyms:

  KN motif and ankyrin repeat domain-containing protein 1|Ankyrin repeat domain-containing protein 15|Kidney ankyrin repeat-containing protein|KANK1|ANKRD15|KANK|KIAA0172

• Gene ID:

  23189

• UniProt:

  Q14678

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  KN motif and ankyrin repeat domains 1

• Target:

  KANK1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IF, IHC, WB

• Field of Research:

  Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  150 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IF, IHC, WB