KANK2 antibody

• Background :

  Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081) . May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500) . May be involved in promotion of cell proliferation (By similarity) .

• Synonyms :

  KN motif and ankyrin repeat domain-containing protein 2|Ankyrin repeat domain-containing protein 25|Matrix-remodeling-associated protein 3|SRC-1-interacting protein (SIP, SRC-interacting protein, SRC1-interacting protein) |KANK2|ANKRD25|KIAA1518|MXRA3|SIP

• Gene ID :

  25959

• UniProt :

  Q63ZY3

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  KN motif and ankyrin repeat domains 2

• Target :

  KANK2

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IF

• Field of Research :

  Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  95 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IF