Products for Research Use Only
RegisterLogin

BCA

CAT: 0804-HY-15908-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15908-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) [1][2][3].
CAS Number
979-88-4
Product Name Alternative
Disodium bicinchoninate
UNSPSC
12352200
Hazard Statement
H315, H319, H335
Target
Beta-secretase
Type
Biochemical Assay Reagents
Related Pathways
Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BCA.html
Concentration
10mM
Purity
99.99
Solubility
7.5% Sodium bicarbonate : ≥ 50 mg/mL|DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
Molecular Formula
C20H10N2Na2O4
Molecular Weight
388.29
Precautions
H315, H319, H335
References & Citations
[1]Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25 (9) :2158-63.|[2]Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056.|[3]Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8 (10) :637.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
BACE1

Chemical Information

[2,2'-Biquinoline]-4,4'-dicarboxylic acid, sodium salt (1:2)
CAS Number979-88-4
PubChem CID164763
IUPAC Namedisodium;2-(4-carboxylatoquinolin-2-yl)quinoline-4-carboxylate
Molecular FormulaC20H10N2Na2O4
Molecular Weight388.3
Topological Polar Surface Area106
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count28
Formal Charge0
Complexity495
SMILES
C1=CC=C2C(=C1)C(=CC(=N2)C3=NC4=CC=CC=C4C(=C3)C(=O)[O-])C(=O)[O-].[Na+].[Na+]
InChI
InChI=1S/C20H12N2O4.2Na/c23-19(24)13-9-17(21-15-7-3-1-5-11(13)15)18-10-14(20(25)26)12-6-2-4-8-16(12)22-18;;/h1-10H,(H,23,24)(H,25,26);;/q;2*+1/p-2
InChIKey
AUPXFICLXPLHBB-UHFFFAOYSA-L
Chemical Structure
2D Structure
2D structure of [2,2'-Biquinoline]-4,4'-dicarboxylic acid, sodium salt (1:2)
CAS: 979-88-4
CID: 164763
Formula: C20H10N2Na2O4
MW: 388.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass388.04359537
Monoisotopic Mass388.04359537
Topological Polar Surface Area106 Ų
Heavy Atom Count28
Formal Charge0
Complexity495
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-153878-01BCAT-IN-4
HY-141668-01BCAT-IN-1
HY-141669-01BCAT-IN-2
HY-P700662-01BCAM, Cynomolgus (HEK293, His)
HY-P72845-01BCAM, Rat (HEK293, His)
HY-P7648-01BCAM, Human (HEK293, His)
HY-P72844-01BCAM, Mouse (HEK293, His)
HY-P7676-01BCAN, Human (HEK293, His)
HY-P75479BCAM, Mouse (HEK293, Fc)
HY-RS17632Bcam Mouse Pre-designed siRNA Set A

Alternative Products

CatalogName
303-150Riboclear (RNA Cleanup)
TBS10485-100Tribio InVivoMAb Anti-Mouse TIGIT & PD-L1 Bispecific Antibody
TBS10191-1mgTetrahydrocannabinol (THC) Monoclonal Antibody
TBI3024-25MGAc-Leu-Leu-Nle-CHO (ALLN), Calpain inhibitor
122-101ExgeneTM Forensic SV mini
TBS10483-100Tribio InVivoMAb Anti-Mouse PD-L1 & CD28 Bispecific Antibody
TBS10183-1mgMonoclonal Anti-Thyroid Stimulating Hormone (TSH) Antibody
TBS10340-0.5MGInVivo Mouse IgG1 Isotype Control Antibody
121-220Exfection Plasmid EF (Exdotoxin Free, Midi)
TBS10482-100Tribio InVivoMAb Anti-Mouse PD-L1 & OX40 Bispecific Antibody

Popular Products