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BCA

CAT: 0804-HY-15908-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-15908-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) [1][2][3].
CAS Number
979-88-4
Product Name Alternative
Disodium bicinchoninate
UNSPSC
12352200
Hazard Statement
H315, H319, H335
Target
Beta-secretase
Type
Biochemical Assay Reagents
Related Pathways
Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BCA.html
Concentration
10mM
Purity
99.99
Solubility
7.5% Sodium bicarbonate : ≥ 50 mg/mL|DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
Molecular Formula
C20H10N2Na2O4
Molecular Weight
388.29
Precautions
H315, H319, H335
References & Citations
[1]Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25 (9) :2158-63.|[2]Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056.|[3]Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8 (10) :637.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
BACE1

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