BCA

• Description :

  BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) [1][2][3].

• Product Name Alternative :

  Disodium bicinchoninate

• UNSPSC :

  12352200

• Hazard Statement :

  H315, H319, H335

• Target :

  Beta-secretase

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/BCA.html

• Concentration :

  10mM

• Purity :

  99.99

• Solubility :

  7.5% Sodium bicarbonate : ≥ 50 mg/mL|DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4

• Molecular Formula :

  C20H10N2Na2O4

• Molecular Weight :

  388.29

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25 (9) :2158-63.|[2]Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056.|[3]Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8 (10) :637.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• Isoform :

  BACE1

• CAS Number :

  [979-88-4]