IRF9 antibody

CAT: 0710-FNab04397Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab04397Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Synonyms

Gene ID

10379

UniProt

Q00978

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Interferon regulatory factor 9

Target

IRF9

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC, IF, IP

Field of Research

Epigenetics, Signal Transduction, Metabolism, Cancer, Immunology

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

48 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC, IF, IP

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