ERBB2 antibody

CAT: 0710-FNab03833Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab03833Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185-kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.
Synonyms
Receptor tyrosine-protein kinase erbB-2|Metastatic lymph node gene 19 protein (MLN 19) |Proto-oncogene Neu|Proto-oncogene c-ErbB-2|Tyrosine kinase-type cell surface receptor HER2|p185erbB2|ERBB2|HER2|MLN19|NEU|NGL
Gene ID
2064
UniProt
P04626
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Target
ERBB2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, FC, IP
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:10000; IP: 1:200-1:2000; IHC: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
185 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, FC, IP

Related Products

CatalogName
Pr10135-01Recombinant Human ERBB2
P10135-01Recombinant Human ERBB2
P4532-01Recombinant Rat Erbb2
P10113-01Recombinant Rat Erbb2
Pr10113-01Recombinant Rat Erbb2
ER0606Rat Erbb2 (Receptor tyrosine-protein kinase erbB-2) ELISA Kit
EM0314Mouse Erbb2 (Receptor tyrosine-protein kinase erbB-2) ELISA Kit
QT-ER0606Rat Erbb2 (Receptor tyrosine-protein kinase erbB-2) QuickTest ELISA Kit
FNab02828ERBB3 antibody
FNab02829ERBB4 antibody

Alternative Products

CatalogName
MBS8594418-01ERBB2 Antibody

Popular Products