ERBB4 antibody

• Background:

  This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

• Synonyms:

  Receptor tyrosine-protein kinase erbB-4|Proto-oncogene-like protein c-ErbB-4|Tyrosine kinase-type cell surface receptor HER4|p180erbB4|ERBB4 intracellular domain (4ICD, E4ICD) Alternative names: s80HER4|ERBB4|HER4

• Gene ID:

  2066

• UniProt:

  Q15303

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Immunogen:

  V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

• Target:

  ERBB4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC, WB

• Field of Research:

  Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  180 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IHC, WB