ERBB3 antibody

CAT: 0710-FNab02828Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab02828Size:100 µg
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Background
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) .
Synonyms
Receptor tyrosine-protein kinase erbB-3|Proto-oncogene-like protein c-ErbB-3|Tyrosine kinase-type cell surface receptor HER3|ERBB3|HER3
Gene ID
2065
UniProt
P21860
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3
Target
ERBB3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Cancer, Immunology
Purification
Immunogen affinity purified
Dilution
IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC

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