ERBB3 antibody

• Background:

  Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) .

• Synonyms:

  Receptor tyrosine-protein kinase erbB-3|Proto-oncogene-like protein c-ErbB-3|Tyrosine kinase-type cell surface receptor HER3|ERBB3|HER3

• Gene ID:

  2065

• UniProt:

  P21860

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  V-erb-b2 erythroblastic leukemia viral oncogene homolog 3

• Target:

  ERBB3

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IHC

• Field of Research:

  Signal Transduction, Metabolism, Cardiovascular, Cancer, Immunology

• Purification:

  Immunogen affinity purified

• Dilution:

  IHC: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IHC