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GSK3B antibody

CAT: 0710-FNab03674Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03674Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase.GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.In skeletal muscle, it contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Researches showed that the crystal structure of human GSK3B, expressed in insect cells, at 2.8-angstrom resolution.This antibody recognize the C-terminal of GSK3B.
Synonyms
Glycogen synthase kinase-3 beta (GSK-3 beta) |Serine/threonine-protein kinase GSK3B|GSK3B
Gene ID
2932
UniProt
P49841
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Glycogen synthase kinase 3 beta
Target
GSK3B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC, IP
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:100-1:400; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC, IP

UniProtKB · P49841

Glycogen synthase kinase-3 beta

GSK3B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49841
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GSK3B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GSK-3 beta
EC number
2.7.11.26
Processing
—
Secondary accessions
D3DN89, Q9BWH3, Q9UL47
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

ADP-ribosylationLipoproteinPalmitatePhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseDiabetes mellitus

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythmsCarbohydrate metabolismDifferentiationGlycogen metabolismNeurogenesisWnt signaling pathway

Cellular component

Cell membraneCytoplasmMembraneNucleus

Molecular function

Developmental proteinKinaseSerine/threonine-protein kinaseSignal transduction inhibitorTransferase

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