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ELOVL4 antibody

CAT: 0710-FNab02747Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02747Size:100 µg
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Background
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long-and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
Synonyms
Very long chain fatty acid elongase 4|3-keto acyl-CoA synthase ELOVL4|ELOVL fatty acid elongase 4 (ELOVL FA elongase 4) |Elongation of very long chain fatty acids protein 4|Very long chain 3-ketoacyl-CoA synthase 4|Very long chain 3-oxoacyl-CoA synthase 4|ELOVL4
Gene ID
6785
UniProt
Q9GZR5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast) -like 4
Target
ELOVL4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
37-40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · Q9GZR5

Very long chain fatty acid elongase 4

ELOV4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9GZR5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ELOVL4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.199
Processing
—
Secondary accessions
B2R6B5, Q5TCS2, Q86YJ1, Q9H139
Protein keywords

Disease

Disease variantIchthyosisIntellectual disabilityNeurodegenerationSpinocerebellar ataxiaStargardt disease

Cellular component

Endoplasmic reticulumMembrane

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

PTM

Glycoprotein

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

Domain

TransmembraneTransmembrane helix

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