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ELOVL2 antibody

CAT: 0710-FNab02746Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02746Size:100 µg
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Background
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long-and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4 (n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20-and C22-PUFA) . May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Synonyms
Very long chain fatty acid elongase 2|3-keto acyl-CoA synthase ELOVL2|ELOVL fatty acid elongase 2 (ELOVL FA elongase 2) |Elongation of very long chain fatty acids protein 2|Very long chain 3-ketoacyl-CoA synthase 2|Very long chain 3-oxoacyl-CoA synthase 2|ELOVL2|ELG3|SSC2
Gene ID
54898
UniProt
Q9NXB9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast) -like 2
Target
ELOVL2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC

UniProtKB · Q9NXB9

Very long chain fatty acid elongase 2

ELOV2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NXB9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ELOVL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.199
Processing
—
Secondary accessions
Q6P9E1, Q86W94
Protein keywords

Cellular component

Endoplasmic reticulumMembrane

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

Domain

TransmembraneTransmembrane helix

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