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CYP46A1 antibody

CAT: 0710-FNab02167Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02167Size:100 µg
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Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Synonyms
Cholesterol 24-hydroxylase (CH24H) |Cholesterol 24-monooxygenase|Cholesterol 24S-hydroxylase|Cytochrome P450 46A1|CYP46A1|CYP46
Gene ID
10858
UniProt
Q9Y6A2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Cytochrome P450, family 46, subfamily A, polypeptide 1
Target
CYP46A1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q9Y6A2

Cholesterol 24-hydroxylase

CP46A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6A2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP46A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CH24H
EC number
1.14.14.25
Processing
—
Secondary accessions
B4DHP8, E7EQG9, Q8N2B0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionEndoplasmic reticulumMembraneMicrosomeSynapse

Biological process

Cholesterol metabolismLipid metabolismSteroid metabolismSterol metabolism

Ligand

HemeIronMetal-binding

Molecular function

MonooxygenaseOxidoreductase

Domain

TransmembraneTransmembrane helix

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