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CYP17A1 antibody

CAT: 0710-FNab02145Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02145Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Synonyms
Steroid 17-alpha-hydroxylase/17,20 lyase|17-alpha-hydroxyprogesterone aldolase|CYPXVII|Cytochrome P450 17A1|Cytochrome P450-C17 (Cytochrome P450c17) |Steroid 17-alpha-monooxygenase|CYP17A1|CYP17|S17AH
Gene ID
1586
UniProt
P05093
Host
Rabbit
Reactivity
Human
Immunogen
Cytochrome P450, family 17, subfamily A, polypeptide 1
Target
CYP17A1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48-51 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
322-508aa

UniProtKB · P05093

Steroid 17-alpha-hydroxylase/17,20 lyase

CP17A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05093
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP17A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.14.19
Processing
—
Secondary accessions
Q5TZV7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

Congenital adrenal hyperplasiaDisease variant

Cellular component

Endoplasmic reticulumMembraneMicrosome

Ligand

HemeIronMetal-binding

Biological process

Lipid metabolismSteroidogenesis

Molecular function

LyaseMonooxygenaseOxidoreductase

PTM

Phosphoprotein

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