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CSE1L antibody

CAT: 0710-FNab02012Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02012Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.
Synonyms
Exportin-2 (Exp2) |Cellular apoptosis susceptibility protein|Chromosome segregation 1-like protein|Importin-alpha re-exporter|CSE1L|CAS|XPO2
Gene ID
1434
UniProt
P55060
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
CSE1 chromosome segregation 1-like (yeast)
Target
CSE1L
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cancer, Signal Transduction, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
100-110 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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