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Collagen Type IV antibody

CAT: 0710-FNab01844Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01844Size:100 µg
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Background
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2 (IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and-9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Synonyms
Collagen alpha-2 (IV) chain|Canstatin|COL4A2
Gene ID
1284
UniProt
P08572
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Collagen, type IV, alpha 2
Target
Collagen Type IV
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Cancer, Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
200 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P08572

Collagen alpha-2(IV) chain

CO4A2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08572
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
COL4A2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q14052, Q548C3, Q5VZA9, Q66K23
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Angiogenesis

Cellular component

Basement membraneExtracellular matrixSecreted

PTM

BrominationDisulfide bondGlycoproteinHydroxylation

Domain

CollagenRepeatSignal

Disease

Disease variant

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