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CITED2 antibody

CAT: 0710-FNab01721Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01721Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM) . Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP) ; stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.
Synonyms
Cbp/p300-interacting transactivator 2|MSG-related protein 1 (MRG-1) |P35srj|CITED2|MRG1
Gene ID
10370
UniProt
Q99967
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Target
CITED2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cancer, Cardiovascular, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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