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BCL6 antibody

CAT: 0710-FNab00849Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab00849Size:100 µg
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Background
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4 (+) T-cells (T (FH) cells), promotes the expression of T (FH) -related genes but inhibits the differentiation of T (H) 1, T (H) 2 and T (H) 17 cells. Also required for the establishment and maintenance of immunological memory for both T-and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and-independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
Synonyms
B-cell lymphoma 6 protein (BCL-6) |B-cell lymphoma 5 protein (BCL-5) |Protein LAZ-3|Zinc finger and BTB domain-containing protein 27|Zinc finger protein 51|BCL6|BCL5|LAZ3|ZBTB27|ZNF51
Gene ID
604
UniProt
P41182
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
B-cell CLL/lymphoma 6
Target
BCL6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cancer, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:3000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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