Bcl-XL antibody

CAT: 0710-FNab00842Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab00842Size:100 µg

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Background

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X (L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F (1) F (0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) . Isoform Bcl-X (S) promotes apoptosis.

Synonyms

Bcl-2-like protein 1 (Bcl2-L-1) |Apoptosis regulator Bcl-X|BCL2L1|BCL2L|BCLX

Gene ID

598

UniProt

Q07817

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

BCL2-like 1

Target

Bcl-XL

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC, IF, WB

Field of Research

Neuroscience, Cancer, Immunology, Cardiovascular

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

30 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IHC, IF, WB

UniProtKB · Q07817

Bcl-2-like protein 1

B2CL1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q07817
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BCL2L1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Bcl2-L-1
EC number: —
Processing: —
Secondary accessions: E1P5L6, Q5CZ89, Q5TE65, Q92976

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisEndocytosis

Cellular component

CytoplasmCytoplasmic vesicleCytoskeletonMembraneMitochondrionMitochondrion inner membraneMitochondrion outer membraneNucleusSynapse

PTM

PhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix

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Alternative Products

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70R-34417	BCL-XL antibody
GWB-49B9FE	bcl-XL, Antibody
MBS835753-01	BCL XL antibody