BCL2 antibody

• Background :

  Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .

• Synonyms :

  Apoptosis regulator Bcl-2|BCL2

• Gene ID :

  596

• UniProt :

  P10415

• Host :

  Mouse

• Reactivity :

  Human

• Immunogen :

  B-cell CLL/lymphoma 2

• Target :

  BCL2

• Clonality :

  Monoclonal

• Isotype :

  IgG2a

• Applications :

  ELISA, WB, IP, IHC

• Field of Research :

  Neuroscience, Cancer, Immunology, Cardiovascular

• Purification :

  Protein A+G purification

• Dilution :

  WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  26 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  8A10

• Tested Applications :

  ELISA, WB, IP, IHC

• Immunogen Sequence :

  1-239aa