BCL2 antibody

• Background:

  Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .

• Synonyms:

  Apoptosis regulator Bcl-2|BCL2

• Gene ID:

  596

• UniProt:

  P10415

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  B-cell CLL/lymphoma 2

• Target:

  BCL2

• Clonality:

  Monoclonal

• Isotype:

  IgG2a

• Applications:

  ELISA, WB, IP, IHC

• Field of Research:

  Neuroscience, Cancer, Immunology, Cardiovascular

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  26 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  8A10

• Tested Applications:

  ELISA, WB, IP, IHC

• Immunogen Sequence:

  1-239aa