ATG4D antibody

• Background:

  Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

• Synonyms:

  Cysteine protease ATG4D|AUT-like 4 cysteine endopeptidase|Autophagy-related cysteine endopeptidase 4 (Autophagin-4) |Autophagy-related protein 4 homolog D (HsAPG4D) |Cysteine protease ATG4D, mitochondrial|ATG4D|APG4D|AUTL4

• Gene ID:

  84971

• UniProt:

  Q86TL0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  ATG4 autophagy related 4 homolog D

• Target:

  ATG4D

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Cardiovascular, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:1000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  53 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB