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ATG4D antibody

CAT: 0710-FNab00676Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00676Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
Synonyms
Cysteine protease ATG4D|AUT-like 4 cysteine endopeptidase|Autophagy-related cysteine endopeptidase 4 (Autophagin-4) |Autophagy-related protein 4 homolog D (HsAPG4D) |Cysteine protease ATG4D, mitochondrial|ATG4D|APG4D|AUTL4
Gene ID
84971
UniProt
Q86TL0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ATG4 autophagy related 4 homolog D
Target
ATG4D
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
53 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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