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ARHGEF5 antibody

CAT: 0710-FNab00563Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00563Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624) . Strongly activates RHOA (PubMed:15601624) . Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity) . Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624) . Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653) . Required for SRC-induced podosome formation (By similarity) . Involved in positive regulation of immature dendritic cell migration (By similarity) .
Synonyms
Rho guanine nucleotide exchange factor 5|Ephexin-3|Guanine nucleotide regulatory protein TIM|Oncogene TIM|Transforming immortalized mammary oncogene|p60 TIM|ARHGEF5|TIM
Gene ID
7984
UniProt
Q12774
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Rho guanine nucleotide exchange factor (GEF) 5
Target
ARHGEF5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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