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SERPINC1 antibody

CAT: 0710-FNab00449Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00449Size:100 µg
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Background
SERPINC1, also named Antithrombin III or Antithrombin, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Synonyms
Antithrombin-III (ATIII) |Serpin C1|SERPINC1|AT3
Gene ID
462
UniProt
P01008
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Serpin peptidase inhibitor, clade C (antithrombin), member 1
Target
SERPINC1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Cardiovascular, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
53 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9A4
Tested Applications
ELISA, WB
Immunogen Sequence
1-259aa

UniProtKB · P01008

Antithrombin-III

ANT3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01008
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SERPINC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ATIII
EC number
—
Processing
Precursor
Secondary accessions
B2R6P0, P78439, P78447, Q13815, Q5TC78, Q7KZ43, Q7KZ97, Q9UC78
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Blood coagulationHemostasis

Disease

Disease variantThrombophilia

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

Heparin-bindingProtease inhibitorSerine protease inhibitor

Cellular component

Secreted

Domain

Signal

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