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SERPINA1 antibody

CAT: 0710-FNab00338Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00338Size:100 µg
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Background
SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
Synonyms
Alpha-1-antitrypsin|Alpha-1 protease inhibitor|Alpha-1-antiproteinase|Serpin A1|Short peptide from AAT (SPAAT) |SERPINA1|AAT|PI
Gene ID
5265
UniProt
P01009
Host
Mouse
Reactivity
Human, Rat
Immunogen
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Target
SERPINA1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Immunology, Cardiovascular, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IP: 1:500-1:2000; IF: 1:20-1:200; IHC: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
5B1
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
28-418aa

UniProtKB · P01009

Alpha-1-antitrypsin

A1AT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01009
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SERPINA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A6PX14, B2RDQ8, Q0PVP5, Q13672, Q53XB8, Q5U0M1, Q7M4R2, Q86U18, Q86U19, Q96BF9, Q96ES1, Q9P1P0, Q9UCE6, Q9UCM3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Acute phaseBlood coagulationHemostasis

Coding sequence diversity

Alternative splicing

Cellular component

Endoplasmic reticulumExtracellular matrixSecreted

PTM

GlycoproteinPhosphoprotein

Molecular function

Protease inhibitorSerine protease inhibitor

Domain

Signal

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