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AGT antibody

CAT: 0710-FNab00395Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00395Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Synonyms
Angiotensinogen|Serpin A8|Angiotensin-1 Alternative names: Angiotensin 1-10|Angiotensin I (Ang I) |Angiotensin-2 Alternative names: Angiotensin 1-8|Angiotensin II (Ang II) |Angiotensin-3 Alternative names: Angiotensin 2-8|Angiotensin III (Ang III) |Des-Asp[1]-angiotensin II|Angiotensin-4 Alternative names: Angiotensin 3-8|Angiotensin IV (Ang IV) |Angiotensin 1-9|Angiotensin 1-7|Angiotensin 1-5|Angiotensin 1-4|AGT|SERPINA8
Gene ID
183
UniProt
P01019
Host
Mouse
Reactivity
Human
Immunogen
Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Target
AGT
Clonality
Monoclonal
Isotype
IgG2b
Applications
ELISA, WB, IHC
Field of Research
Cardiovascular, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
53 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
0F2
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
150-485aa

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