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ALKBH7 antibody

CAT: 0710-FNab00315Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00315Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757) . Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923) . ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923) . Does not display DNA demethylase activity (PubMed:23666923) . Involved in fatty acid metabolism (By similarity) .
Synonyms
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial|Alkylated DNA repair protein alkB homolog 7|Spermatogenesis cell proliferation-related protein|Spermatogenesis-associated protein 11|ALKBH7|ABH7|SPATA11
Gene ID
84266
UniProt
Q9BT30
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
AlkB, alkylation repair homolog 7 (E. coli)
Target
ALKBH7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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