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ALKBH1 antibody

CAT: 0710-FNab00311Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00311Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dioxygenase that acts as a DNA demethylase (PubMed:18603530) . Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:18603530) . Specifically demethylates DNA methylated on the 6th position of adenine (N (6) -methyladenosine) DNA. N (6) -methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing (By similarity) . Also able to repair alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation, but with low activity (PubMed:18603530) . Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites (PubMed:19959401) . DNA lyase activity does not require alpha-ketoglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product (PubMed:19959401, PubMed:23577621) . DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation (By similarity) .
Synonyms
Nucleic acid dioxygenase ALKBH1|Alkylated DNA repair protein alkB homolog 1|Alpha-ketoglutarate-dependent dioxygenase ABH1|DNA 6mA demethylase|DNA N6-methyl adenine demethylase ALKBH1|DNA lyase ABH1|DNA oxidative demethylase ALKBH1|mRNA N (3) -methylcytidine demethylase|ALKBH1|ABH|ABH1|ALKBH
Gene ID
238
UniProt
Q13686
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
AlkB, alkylation repair homolog 1 (E. coli)
Target
ALKBH1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
44 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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