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AKT3 antibody

CAT: 0710-FNab00273Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00273Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Synonyms
RAC-gamma serine/threonine-protein kinase|Protein kinase Akt-3|Protein kinase B gamma (PKB gamma) |RAC-PK-gamma|STK-2|AKT3|PKBG
Gene ID
10000
UniProt
Q9Y243
Host
Rabbit
Reactivity
Human, Mouse, Rat, Zebrafish
Immunogen
V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Target
AKT3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
Peptide

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