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AKT1 antibody

CAT: 0710-FNab00271Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00271Size:100 µg
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Background
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. This antibody detects all the members of AKT with/without phospho-modification.
Synonyms
RAC-alpha serine/threonine-protein kinase|Protein kinase B (PKB) |Protein kinase B alpha (PKB alpha) |Proto-oncogene c-Akt|RAC-PK-alpha|AKT1|PKB|RAC
Gene ID
207
UniProt
P31749
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
V-akt murine thymoma viral oncogene homolog 1
Target
AKT1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:400; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
56-62 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
8H0
Tested Applications
ELISA, WB, IHC, IF, IP
Immunogen Sequence
1-220aa

UniProtKB · P31749

RAC-alpha serine/threonine-protein kinase

AKT1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P31749
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AKT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B2RAM5, B7Z5R1, Q9BWB6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCarbohydrate metabolismGlucose metabolismGlycogen biosynthesisGlycogen metabolismNeurogenesisSugar transportTranslation regulationTransport

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembraneMitochondrionNucleus

Molecular function

Developmental proteinKinaseSerine/threonine-protein kinaseTransferase

Disease

Disease variantProto-oncogene

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