ADAM17-Specific antibody

• Background:

  The ADAMs(A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor(TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.

• Synonyms:

  Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)|Snake venom-like protease|TNF-alpha convertase|TNF-alpha-converting enzyme|ADAM17|CSVP|TACE

• Gene ID:

  6868

• UniProt:

  P78536

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  ADAM metallopeptidase domain 17

• Target:

  ADAM17

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  29 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

• CAS Number:

  9007-83-4