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G-quadruplex ligand 2

CAT: 0804-HY-158126Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158126Size:1 Each
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Description
G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the cGAS-STING pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME[1].
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g-quadruplex-ligand-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)N(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)/C=C/C4=[N+](C5=C(C4(C)C)C6=C(C=C5)C=CC=C6)C.[I-]
Molecular Formula
C37H35IN2O2
Molecular Weight
666.59
References & Citations
[1]Xiao-Dong Wang, et al. Discovery of a triphenylamine-based ligand that targets mitochondrial DNA G-quadruplexes and activates the cGAS-STING immunomodulatory pathway. Eur J Med Chem. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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