G-quadruplex ligand 2

• UNSPSC Description:

  G-quadruplex ligand 2 (compound A3) is a triphenylamine-based ligand that targets mitochondrial DNA G4s. G-quadruplex ligand 2 activates the cGAS-STING pathway. G-quadruplex ligand 2 inhibits tumor growth and metastasis via regulation of TME[1].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/g-quadruplex-ligand-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(C=C1)N(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)/C=C/C4=[N+](C5=C(C4(C)C)C6=C(C=C5)C=CC=C6)C.[I-]

• Molecular Weight:

  666.59

• References & Citations:

  [1]Xiao-Dong Wang, et al. Discovery of a triphenylamine-based ligand that targets mitochondrial DNA G-quadruplexes and activates the cGAS-STING immunomodulatory pathway. Eur J Med Chem. 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported