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Crisaborole (Standard)

CAT: 0804-HY-10978R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10978R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Crisaborole (Standard) is the analytical standard of Crisaborole. This product is intended for research and analytical applications. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.
CAS Number
906673-24-3
Product Name Alternative
AN-2728 (Standard) ; PF-06930164 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/crisaborole-standard.html
Purity
99.95
Smiles
N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1
Molecular Formula
C14H10BNO3
Molecular Weight
251.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19 (8) :2129-32.|[2]Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10 (11) :1236-42.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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