(all-E) -UAB30

• Description:

  (all-E) -UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist. (all-E) -UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively[1][2].

• Product Name Alternative:

  UAB30

• UNSPSC:

  12352005

• Target:

  RAR/RXR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/all-e-uab30.html

• Smiles:

  O=C(O)/C=C(C)/C=C/C=C(C)/C=C1CCCC2=C\1C=CC=C2

• Molecular Formula:

  C20H22O2

• Molecular Weight:

  294.39

• References & Citations:

  [1]Adele P. Williams, et al. UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts. Transl Oncol. 2019 Oct;12 (10) :1364-1374.|[2]Chu-Fang Chou, et al. The Retinoid X Receptor Agonist, 9-cis UAB30, Inhibits Cutaneous T-cell Lymphoma Proliferation Through the SKP2-p27kip1 Axis. J Dermatol Sci. 2018 Jun; 90 (3) : 343–356.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [205252-59-1]