Products for Research Use Only
RegisterLogin

9-cis-UAB30

CAT: 0804-HY-129108Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-129108Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs) . 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43) . 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer[1][2][3].
CAS Number
205252-57-9
Product Name Alternative
(9Z) -UAB-30
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E1/E2/E3 Enzyme; Microtubule/Tubulin; Oct3/4; Proteasome
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer; Neurological Disease
Smiles
O=C(O)/C=C(C)/C=C/C=C(C)\C=C1CCCC2=C/1C=CC=C2
Molecular Formula
C20H22O2
Molecular Weight
294.39
Precautions
P261-P280-P302+P352
References & Citations
[1]Marayati R, et al. 9-cis-9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts. Transl Oncol. 2021 Jan;14 (1) :100893.|[2]Chou CF, et al. The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. J Dermatol Sci. 2018 Jun;90 (3) :343-356.|[3]Lindeblad M, et al. Assessment of oral toxicity and safety of 9-cis-UAB30, a potential chemopreventive agent, in rat and dog studies. Drug Chem Toxicol. 2011 Jul;34 (3) :300-10.|[4]Kapetanovic IM, et al. Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention. Int J Toxicol. 2010 Mar-Apr;29 (2) :157-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Skp2

Related Products

CatalogName
HY-117376(all-E) -UAB30
HY-W127323Cis-9-Hexadecenol
HY-W009310-019-cis-Retinal
HY-W7506789-cis-Canthaxanthin
HY-1655429-cis-Astaxanthin
HY-136234-019-cis-β-Carotene
HY-W5878069-cis Retinol
HY-N15316Cis-9, cis-12-Heptadecadienoic acid
HY-142107S-019-cis,13-cis-Retinol-d5
HY-142016Retinol, palmitate, 9-cis,13-cis-

Alternative Products

CatalogName
T89591-01(all-E) -UAB30
R16599-cis Retinal (9-cis-Retinaldehyde, 9-cis-Vitamin A aldehyde, Isoretinene a)
sc-234395Cis, cis-1,9-Cyclohexadecadiene
sc-477237A9-cis,13-cis-Retinol
RM-V307943-019,13-Cis, Cis Vitamin A
0205929-cis-Retinol
TRC-A189910-25MG9-cis Acitretin
RM-L030501-019-cis-Lycopene
MBS57559389-cis-Retinal
sc-2072179-cis Retinal

Popular Products