9-cis-UAB30

• Description:

  9-cis-UAB30 is a rexinoid agonist. 9-cis-UAB30 significantly decreases the proliferation, viability, and motility of both patient-derived xenografts (PDXs) . 9-cis-UAB30 induced cell-cycle arrest as demonstrated by the significant increase in the percentage of cells in G1 and a decrease in the percentage of cells in S phase by downregulating SKP2 and/or 20S proteasome activity, which leads to increased p27kip1 protein stability. 9-cis-UAB30 downregulates the abundance of stem cell marker mRNAs (Oct4, Nanog, Sox2, nestin) and upregulates the abundance of differentiation marker mRNAs (β3-tubulin, NSE, HOXC9, GAP43) . 9-cis-UAB30 has no adverse effects on the central nervous system and cardiovascular system at the tested dose. 9-cis-UAB30 can be used for the study of neuroblastoma, cutaneous T-cell lymphomas, and breast cancer[1][2][3].

• Product Name Alternative:

  (9Z) -UAB-30

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  E1/E2/E3 Enzyme; Microtubule/Tubulin; Oct3/4; Proteasome

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Field of Research:

  Cancer; Neurological Disease

• Smiles:

  O=C(O)/C=C(C)/C=C/C=C(C)\C=C1CCCC2=C/1C=CC=C2

• Molecular Formula:

  C20H22O2

• Molecular Weight:

  294.39

• Precautions:

  P261-P280-P302+P352

• References & Citations:

  [1]Marayati R, et al. 9-cis-9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts. Transl Oncol. 2021 Jan;14 (1) :100893.|[2]Chou CF, et al. The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. J Dermatol Sci. 2018 Jun;90 (3) :343-356.|[3]Lindeblad M, et al. Assessment of oral toxicity and safety of 9-cis-UAB30, a potential chemopreventive agent, in rat and dog studies. Drug Chem Toxicol. 2011 Jul;34 (3) :300-10.|[4]Kapetanovic IM, et al. Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention. Int J Toxicol. 2010 Mar-Apr;29 (2) :157-64.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Skp2

• CAS Number:

  [205252-57-9]