8-OH-DPAT

• Description:

  8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5) .

• Product Name Alternative:

  8-Hydroxy-DPAT

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/8-OH-DPAT.html

• Purity:

  99.87

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=C2CC (N (CCC) CCC) CCC2=CC=C1

• Molecular Formula:

  C16H25NO

• Molecular Weight:

  247.38

• References & Citations:

  [1]DEREK N. MIDDLEMISS, et al. 8-HYDROXY-2- (DI-n-PROPYLAMINO) -TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF|[2]Bard JA, et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268 (31) :23422-6.|[3]Mori T, et al. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology (Berl) . 2016 Jun;233 (12) :2343-53.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor;5-HT7 Receptor; mLAG-3; MUC3

• Citation 01:

  Acta Pharmacol Sin. 2025 Oct 9.|J Ethnopharmacol. 2026 Feb 28:357:120876.|Mol Neurobiol. 2025 Nov 24;63 (1) :163.|Nature. 2024 Jun;630 (8015) :237-246.|Neurochem Int. 2025 Jan 28:105937.|SSRN. 2025 Jun 19.|Eur J Pharmacol. 2023 Dec 5:960:176147.

• CAS Number:

  78950-78-4