YAP-TEAD-IN-2

YAP-TEAD-IN-2

• CAS Number: 2714432-83-2
• UNSPSC Description: YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor with IC50 is 2.7 nM[1].
• Target Antigen: YAP
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/yap-tead-in-2.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: NC[C@]1(CC2=[C@@](C(Cl)=CC=C2O1)[C@@]3=C(C(N)=O)C=CC(OCCOC)=C3F)C4=CC=CC=C4
• Molecular Weight: 470.92
• References & Citations: [1]Furet P, et al. The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition. ChemMedChem. 2022 Oct 6;17(19):e202200303.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported